London School of Hygiene & Tropical Medicine Clinical Trials Unit

Sponsorship

We prefer not to take the sponsorship role but have flexibility

Particular areas of interest or experience in cardiovascular trial design and delivery

The LSHTM CTU cardiovascular team specialises in the design, conduct and analysis of pragmatic multicentre clinical trials, often with simple interventions or treatment strategies.
We have developed strong links with many of the top cardiovascular hospitals in the UK over the past 30 years, beginning with the BHF-funded RITA, RITA-2 and RITA-3 trials. Through these collaborations with sites we aim to develop efficient trials which can be conducted with minimal complexity while delivering important results.
We are also strongly committed to Patient and Public Involvement (PPI), and work in close collaboration with Cardiovascular PPI representatives at each stage of research from design to dissemination of results.
As well as trial design, conduct and management we have world renowned expertise in statistical methodology, analysis and interpretation of large scale cardiovascular trials. This includes development of novel statistical methods (such as the Win Ratio) and publication of educational articles specifically in the design and analysis of cardiovascular trials.
We also support the statistical design, data monitoring, analysis and publication for a larger set of major industry sponsored international cardiovascular trials.
We have direct experience in delivering emergency research in the NHS, for example in advance of primary percutaneous coronary intervention (PCI) (ERIC-PPCI) or in cardiac arrest (ARREST), or within primary care (StatinWISE). We have worked on trials in coronary artery bypass surgery (ERICCA, RITA, RITA-2, Tight K), remote ischaemic pre-conditioning (ERICCA, ERIC-PPCI, REPAIR), PCI (RITA, RITA-2, RITA-3, REVIVED, ERIC-PPCI, CHIP-BCIS3) and transcatheter aortic valve implantation (BHF PROTECT-TAVI).

• ERIC-PPCI – https://clinicaltrials.gov/ct2/show/NCT02342522
• REVIVED – https://clinicaltrials.gov/ct2/show/NCT01920048
• ERICCA – https://clinicaltrials.gov/ct2/show/NCT01247545
• BHF PROTECT-TAVI – http://www.isrctn.com/ISRCTN16665769
• ARREST – http://www.isrctn.com/ISRCTN96585404

Address: Keppel Street, London, WC1E 6HT

Telephone number: +44 (0)20 7299 4684

Email address: ctu@lshtm.ac.uk

Website: https://ctu.lshtm.ac.uk/