Leeds Institute of Clinical Trials Research

Sponsorship

We can take the sponsorship role but have flexibility

Particular areas of interest or experience in cardiovascular trial design and delivery

We are a leading UK academic clinical trials unit with a track-record in design, conduct and analysis of both early and late-phase high-quality academic clinical trials, influencing national and international clinical practice. Our research is conducted through the Clinical Trials Research Unit (CTRU) and our cardiovascular portfolio sits within the Surgical Interventions, Diagnostics and Devices (SIDD) Division. Our experience ranges from definitive, large-scale, international, randomised controlled trials to single-centre, earlier-phase research including feasibility and qualitative work; together with methodological research investigating real-world challenges of surgical and device evaluations.
Within our cardiovascular portfolio, the focus on surgical interventions, surgical devices and diagnostic devices (including algorithmic interventions), allows us to specialise in innovative and efficient trial design and delivery in these areas. Specifically, our research to date has included a series of studies aiming to identify optimal methods of imaging for accurate diagnosis of cardiovascular disease, risk stratification in treatment approaches, utilising real world evidence and international meta-analysis.

• The UKGRIS trial (in analysis)
  Evaluation of the impact of the GRACE risk score on the management and outcome of patients hospitalised with non-ST elevation acute coronary syndrome in the UK. http://dx.doi.org/10.1136/bmjopen-2019-032165
• The CE MARC Trial (published)
  Cardiovascular magnetic resonance and single-photon emission computed tomography for diagnosis of coronary heart disease (CE-MARC): a prospective trial. https://doi.org/10.1016/S0140-6736(11)61335-4
• The CE MARC 2 Trial (published)
  Effect of Care Guided by Cardiovascular Magnetic Resonance, Myocardial Perfusion Scintigraphy, or NICE Guidelines on Subsequent Unnecessary Angiography Rates: The CE-MARC 2 Randomized Clinical Trial. https://doi.org/10.1001/jama.2016.12680
• The OPT-C study – Optimising Pacemaker Therapy for Contractility
  Personalized Rate-Response Programming Improves Exercise Tolerance After 6 Months in People With Cardiac Implantable Electronic Devices and Heart Failure: A Phase II Study. https://doi.org/10.1161/CIRCULATIONAHA.119.045066
• The Liberates trial (in analysis)
  A randomised controlled trial of flash glucose monitoring for optimisation of glycaemia in individuals with type 2 diabetes and recent myocardial infarction. https://doi.org/10.1177/1479164120957934

Address: Clinical Trials Research Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, LS2 9JT 

Email address: LICTRComms@leeds.ac.uk

Websites: https://medicinehealth.leeds.ac.uk/leeds-institute-clinical-trials-research, https://medicinehealth.leeds.ac.uk/faculty-/dir-record/research-groups/899/surgical-interventions-diagnostics-and-devices